A NOVEL CRISPR/CAS9-BASED IDURONATE-2-SULFATASE (IDS) KNOCKOUT HUMAN NEURONAL CELL LINE REVEALS EARLIEST PATHOLOGICAL CHANGES

A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes

Abstract Multiple complex intracellular cascades contributing to Hunter syndrome (mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the past years.However, the hierarchy of early cellular abnormalities leading to irreversible neuronal damage is far from being completely understood.To tackle this issue, we have gener

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Effect of rice variety and blending proportion on the proximate compositions, minerals and phytic acid contents of bread from rice-teff blend [version 1; peer review: 2 approved]

Development of bakery products containing rice (Oryza sativa, Linn.) and teff (Eragrostis tef) could have potential Storage Accessories health benefits due to their gluten free nature.Nine experimental runs were generated using custom design by JMP 8 software.The effect of two factors, rice variety (Edeget, X-jigna and Nerica-4) and blending propor

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